A selection of case studies of surgical trials that have involved successful international trial collaborations/networks.

ROLARR
Robotic versus laparoscopic surgery for rectal cancer surgery.

A multi-centre trial comparing laparoscopic surgery against robotic-assisted laparoscopic surgery for rectal cancer, co-ordinated from the Clinical Trials Research Unit at the University of Leeds.

GLiSten
Next Generation intraoperative Lymph node staging for Stratified colon cancer surgery – Developmental phase

A multi-centre CTIMP (Clinical Trial of an Investigational Medicinal Product) aiming to optimise the dose, and then evaluate, oral 5-ALA administration for intra-operative fluorescence diagnosis of metastatic lymph nodes in colon cancer, co-ordinated from the Clinical Trials Research Unit at the University of Leeds

LAVA
Next Generation intraoperative Lymph node staging for Stratified colon cancer surgery – Developmental phase

A multi-centre trial comparing the effectiveness and cost-effectiveness of thermal ablation versus liver resection surgery in high risk patients eligible for liver resection, co-ordinated from the Clinical Trials Research Unit at the University of Leeds with University College London as Sponsor.

IntAct
Intraoperative Fluorescence Angiography to Prevent Anastomotic Leak in Rectal Cancer Surgery

A non-CTIMP multicentre randomized controlled trial comparing surgery with IFA (intra-operative fluorescence angiography) against standard care (surgery with no IFA) to determine the effect on anastomotic leak in patients undergoing elective anterior resection for rectal cancer.

COMICS
Conventional versus Minimally Invasive extra-corporeal circulation in patients undergoing Cardiac Surgery: a randomised controlled trial

A non-CTIMP multicentre randomised controlled trial comparing conventional heart-lung machines with miniaturised heart-lung machines in cardiac surgery.

VERDICT
Preoperative Volume Replacement vs. usual care in Diabetic patients having CABG surgery: a randomised controlled Trial

A CTIMP RCT that was running as a single centre in the UK, and due to logistical reasons was not recruiting to time and target.

FALCON

A pragmatic multicentre factorial randomised controlled trial testing measures to reduce surgical site infection in low and middle income countries (LMICs).

STAR-TREC

An international multicentre randomised, feasibility study comprising a 1:1:1 randomisation for eligible subjects with a small, clinically localised rectal cancer between; (a) conventional TME Surgery, (b) organ saving with Chemoradiotherapy ± transanal microsurgery and (b) Short course preoperative radiotherapy ± transanal microsurgery.