A selection of case studies of surgical trials that have involved successful international trial collaborations/networks.
A multi-centre trial comparing laparoscopic surgery against robotic-assisted laparoscopic surgery for rectal cancer, co-ordinated from the Clinical Trials Research Unit at the University of Leeds.
A multi-centre CTIMP (Clinical Trial of an Investigational Medicinal Product) aiming to optimise the dose, and then evaluate, oral 5-ALA administration for intra-operative fluorescence diagnosis of metastatic lymph nodes in colon cancer, co-ordinated from the Clinical Trials Research Unit at the University of Leeds
A multi-centre trial comparing the effectiveness and cost-effectiveness of thermal ablation versus liver resection surgery in high risk patients eligible for liver resection, co-ordinated from the Clinical Trials Research Unit at the University of Leeds with University College London as Sponsor.
A non-CTIMP multicentre randomized controlled trial comparing surgery with IFA (intra-operative fluorescence angiography) against standard care (surgery with no IFA) to determine the effect on anastomotic leak in patients undergoing elective anterior resection for rectal cancer.
A non-CTIMP multicentre randomised controlled trial comparing conventional heart-lung machines with miniaturised heart-lung machines in cardiac surgery.
A CTIMP RCT that was running as a single centre in the UK, and due to logistical reasons was not recruiting to time and target.
An international multicentre randomised, feasibility study comprising a 1:1:1 randomisation for eligible subjects with a small, clinically localised rectal cancer between; (a) conventional TME Surgery, (b) organ saving with Chemoradiotherapy ± transanal microsurgery and (b) Short course preoperative radiotherapy ± transanal microsurgery.